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![Ultimate 21-day Italy and Malta Itinerary: Rome to Sicily](https://storage.googleapis.com/bd-app-dev-375714.appspot.com/itineraries/018f946e-2bdc-7a81-953e-243a04e44a1e/location502.jpg)
Ultimate 21-day Italy and Malta Itinerary: Rome to Sicily Itinerary
Last updated: 2024 Jun 14Iconic Rome: Vatican and Colosseum Wonders
Morning
Begin your journey with a delightful breakfast at the renowned Roscioli, known for its pastries and coffee. Afterward, immerse yourself in the rich history of the Vatican Museums (Musei Vaticani), including the Sistine Chapel (Cappella Sistina).
Afternoon
For lunch, savor authentic Roman cuisine at Da Enzo al 29, a local favorite. Then, explore the ancient St. Peter's Basilica (Basilica di San Pietro) and climb to the top of the dome for a panoramic view of the city.
Evening
Conclude your day with a visit to the iconic Colosseum and the Roman Forum (Foro Romano). For dinner, enjoy a meal at Trattoria Da Cesare al Casaletto, known for its traditional Roman dishes.
Bedtime
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![Visit Vatican Museums (Musei Vaticani) in Rome](https://media.tacdn.com/media/attractions-content--1x-1/12/33/15/8e.jpg)
4.27Vatican Museums (Musei Vaticani)
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Vatican Museums (Musei Vaticani)
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![Visit Sistine Chapel (Cappella Sistina) in Rome](https://media.tacdn.com/media/attractions-content--1x-1/12/32/b5/57.jpg)
4.28Sistine Chapel (Cappella Sistina)
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Sistine Chapel (Cappella Sistina)
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![Visit St. Peter's Basilica (Basilica di San Pietro) in Rome](https://media.tacdn.com/media/attractions-content--1x-1/12/3f/40/ed.jpg)
4.37St. Peter's Basilica (Basilica di San Pietro)
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![Visit St. Peter's Basilica (Basilica di San Pietro) in Rome](https://media.tacdn.com/media/attractions-content--1x-1/12/3f/40/ed.jpg)
St. Peter's Basilica (Basilica di San Pietro)
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![Visit Colosseum in Rome](https://media.tacdn.com/media/attractions-content--1x-1/12/32/04/2a.jpg)
4.45Colosseum
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Colosseum
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![Visit Roman Forum (Foro Romano) in Rome](https://media.tacdn.com/media/attractions-content--1x-1/12/3f/5a/c5.jpg)
4.44Roman Forum (Foro Romano)
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![Visit Roman Forum (Foro Romano) in Rome](https://media.tacdn.com/media/attractions-content--1x-1/12/3f/5a/c5.jpg)
Roman Forum (Foro Romano)
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Rome's Hidden Gems: Catacombs and Pantheon
Morning
Enjoy a leisurely breakfast at Pizzarium, a top spot for pizza al taglio. Explore the Catacombs of Rome (Catacombe di Roma) and discover the underground burial sites of early Christians.
Afternoon
Head to the Pantheon, a marvel of ancient Roman engineering. For lunch, try the famous pasta dishes at Da Enzo al 29. Spend the rest of the afternoon strolling through the charming streets of Trastevere.
Evening
Dine at Ristorante Aroma, a rooftop restaurant with stunning views of the city. Afterward, take a romantic evening walk to the Trevi Fountain (Fontana di Trevi).
Bedtime
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![Visit Catacombs of Rome (Catacombe di Roma) in Rome](https://media.tacdn.com/media/attractions-content--1x-1/12/3f/b4/bc.jpg)
4.46Catacombs of Rome (Catacombe di Roma)
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![Visit Catacombs of Rome (Catacombe di Roma) in Rome](https://media.tacdn.com/media/attractions-content--1x-1/12/3f/b4/bc.jpg)
Catacombs of Rome (Catacombe di Roma)
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![Visit Pantheon in Rome](https://media.tacdn.com/media/attractions-content--1x-1/12/3f/3a/be.jpg)
4.63Pantheon
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![Visit Pantheon in Rome](https://media.tacdn.com/media/attractions-content--1x-1/12/3f/3a/be.jpg)
Pantheon
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![Visit Trastevere in Rome](https://media.tacdn.com/media/attractions-content--1x-1/0b/27/8a/3c.jpg)
4.72Trastevere
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Trastevere
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![Visit From Hermanus or Cape Town Shark Cage Diving Experience in Rome](https://cdn.getyourguide.com/img/tour/56555d7da37e2.jpeg/21.jpg)
4.51Trevi Fountain (Fontana di Trevi)
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![Visit From Hermanus or Cape Town Shark Cage Diving Experience in Rome](https://cdn.getyourguide.com/img/tour/56555d7da37e2.jpeg/21.jpg)
Trevi Fountain (Fontana di Trevi)
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Art and Culture: Borghese Gallery and Spanish Steps
Morning
Start your day with a cappuccino at a local cafe and then visit the Borghese Gallery (Galleria Borghese) for a world-class collection of art.
Afternoon
After the gallery, take a leisurely walk to the Spanish Steps (Piazza di Spagna). Enjoy a traditional Roman lunch at Da Enzo al 29.
Evening
In the evening, explore the upscale shopping district around the Spanish Steps. For dinner, indulge in a fine dining experience at Il Pagliaccio.
Bedtime
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![Visit Borghese Gallery (Galleria Borghese) in Rome](https://media.tacdn.com/media/attractions-content--1x-1/12/33/95/b8.jpg)
4.42Borghese Gallery (Galleria Borghese)
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Borghese Gallery (Galleria Borghese)
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![Visit Vienna Tickets to Haus der Musik in Rome](https://cdn.getyourguide.com/img/tour/5badd0783ae32.jpeg/21.jpg)
4.59Spanish Steps (Piazza di Spagna)
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![Visit Vienna Tickets to Haus der Musik in Rome](https://cdn.getyourguide.com/img/tour/5badd0783ae32.jpeg/21.jpg)
Spanish Steps (Piazza di Spagna)
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