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Ultimate 21-Day Route 66 Adventure from San Francisco to Las Vegas

Ultimate 21-Day Route 66 Adventure from San Francisco to Las Vegas Itinerary

Last updated: 2024 Jun 14

Iconic San Francisco Start

Morning

Start your epic Route 66 journey with a classic San Francisco breakfast at Tartine Bakery, known for its delicious pastries and bread. Afterward, take a leisurely walk along the iconic Golden Gate Bridge and enjoy the stunning views of the bay.

Afternoon

For lunch, head to Gary Danko, a renowned fine dining restaurant in the city. Afterward, explore the vibrant neighborhoods of Fisherman's Wharf and North Beach. Don't miss the chance to visit the historic Alcatraz.

Evening

In the evening, have a memorable dinner at The House, known for its intimate atmosphere and delicious fusion cuisine. Afterward, take a leisurely stroll along the Embarcadero and enjoy the beautiful views of the bay.

Bedtime

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4.49
Golden Gate Bridge
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4.34
Fisherman's Wharf
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Cultural and Culinary Delights

Morning

Start your day with a hearty breakfast at Zuni Cafe, a local favorite known for its roast chicken. Afterward, explore the vibrant Mission District and its colorful street art.

Afternoon

For lunch, indulge in Mexican cuisine at La Taqueria, famous for its authentic tacos. Spend the afternoon visiting the Painted Ladies and the Haight-Ashbury neighborhood, known for its hippie culture.

Evening

Enjoy a unique dining experience at Foreign Cinema, where you can savor gourmet food while watching a film. After dinner, explore the lively nightlife of the Castro District.

Bedtime

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4.66
Painted Ladies
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4.44
Haight-Ashbury
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Nature and Wine

Morning

Have a relaxed morning with breakfast at Tartine Bakery. Then, take a day trip to Muir Woods to experience the majestic redwood trees.

Afternoon

For a late lunch, enjoy a picnic at Crissy Field with a takeout from The Slanted Door. Afterward, head to Napa Valley for a wine tasting experience.

Evening

Return to the city and have a leisurely dinner at State Bird Provisions, known for its innovative small plates. End the day with a walk along the San Francisco Bay.

Bedtime

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4.53
Muir Woods
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4.55
Crissy Field
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City Highlights and Bay Cruise

Morning

Start your day with a classic San Francisco breakfast at Tartine Bakery. Then, take a guided tour of the city on a San Francisco Small-Group City Tour by Vintage VW Bus.

Afternoon

For lunch, enjoy the seafood at Swan Oyster Depot, a local institution. In the afternoon, take a San Francisco Golden Gate Bay Cruise to see the city from the water.

Evening

Have a memorable dinner at The House, known for its intimate atmosphere and delicious fusion cuisine. Afterward, take a leisurely stroll along the Embarcadero and enjoy the beautiful views of the bay.

Bedtime

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4.92
San Francisco Small-Group City Tour by Vintage VW Bus
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4.70
San Francisco Golden Gate Bay Cruise
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Art and Architecture

Morning

Start your day with a delicious breakfast at Tartine Bakery. Then, visit the San Francisco Museum of Modern Art to explore its impressive collection.

Afternoon

For lunch, head to The Slanted Door for modern Vietnamese cuisine. Spend the afternoon exploring the Palace of Fine Arts and the Legion of Honor.

Evening

Enjoy a fine dining experience at Gary Danko, known for its impeccable service and exquisite food. After dinner, take a leisurely walk around the Union Square.

Bedtime

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3.99
Palace of Fine Arts
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4.22
Union Square
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Outdoor Adventures

Morning

Start your day with a hearty breakfast at Zuni Cafe. Then, take a San Francisco Golden Gate Bridge and Sausalito Cycling Tour for a scenic ride.

Afternoon

For a late lunch, enjoy the seafood at Swan Oyster Depot, a local institution. Afterward, explore the charming town of Sausalito.

Evening

Have a relaxed dinner at NOPA Kitchen + Bar, known for its seasonal cuisine. End the day with a walk along the San Francisco Bay.

Bedtime

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4.64
San Francisco Golden Gate Bridge and Sausalito Cycling Tour
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4.60
San Francisco Bay
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Farewell to San Francisco

Morning

Enjoy a leisurely breakfast at Tartine Bakery. Then, take a San Francisco Big Bus Hop-On Hop-Off Sightseeing Tour to visit the city's major attractions.

Afternoon

For lunch, have a picnic at Golden Gate Park with a takeout from Tartine Bakery. Spend the afternoon exploring the park and visiting the California Academy of Sciences.

Evening

Have a farewell dinner at Gary Danko, savoring the last moments of your San Francisco culinary experience. Afterward, take a sunset cruise on the San Francisco California Sunset Boat Cruise.

Bedtime

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4.44
San Francisco Big Bus Hop-On Hop-Off Sightseeing Tour
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4.49
Golden Gate Park
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From San Francisco to Los Angeles

Morning

Start your day with a quick breakfast at Tartine Bakery. Then, catch a flight from San Francisco to Los Angeles.

Afternoon

Upon arrival in Los Angeles, have a late lunch at In-N-Out Burger, a must-try for any visitor to the city. Afterward, check into your hotel and take some time to relax.

Evening

For dinner, enjoy the modern American cuisine at Nopa. Afterward, take a leisurely walk along the Santa Monica Pier and enjoy the ocean views.

Bedtime

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4.87
Santa Monica Pier
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City of Angels Exploration

Morning

Start your day with a classic LA breakfast at Eggslut. Then, take a Los Angeles Hop-On Hop-Off Double Decker Bus Tour to get an overview of the city.

Afternoon

For lunch, enjoy the food at Grand Central Market, a bustling food hall in downtown LA. Spend the afternoon visiting the Getty Center and enjoying the art and architecture.

Evening

Have a memorable dinner at Perch, a rooftop restaurant with stunning views of the city. Afterward, explore the nightlife of Downtown Los Angeles.

Bedtime

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Hollywood and Beyond

Morning

Start your day with a breakfast at Blu Jam Cafe. Then, take a Hollywood Celebrity Homes Tour to see the residences of the stars.

Afternoon

For lunch, enjoy the food at Pink's Hot Dogs, a famous LA institution. Spend the afternoon visiting the Hollywood Walk of Fame and the Griffith Observatory.

Evening

Have a glamorous dinner at Catch LA, a celebrity hotspot known for its seafood. Afterward, take a walk along the Sunset Strip and enjoy the vibrant nightlife.

Bedtime

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3.00
Hollywood Walk of Fame
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4.84
Griffith Observatory
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Beach Day in LA

Morning

Start your day with a beachside breakfast at Back on the Beach Cafe. Then, spend the morning relaxing on the Santa Monica Beach.

Afternoon

For lunch, enjoy the seafood at The Lobster, a restaurant with ocean views. In the afternoon, take a Venice Beach and Boardwalk Walking Tour to experience the eclectic atmosphere.

Evening

Have a casual dinner at The Misfit Restaurant + Bar, a local favorite. Afterward, take a sunset stroll along the Santa Monica Pier.

Bedtime

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4.77
Venice Beach and Boardwalk Walking Tour
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4.87
Santa Monica Pier
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Cultural and Culinary Delights

Morning

Start your day with a breakfast at Blu Jam Cafe. Then, visit the Los Angeles County Museum of Art to explore its impressive collection.

Afternoon

For lunch, enjoy the food at The Original Farmers Market, a historic market in LA. Spend the afternoon visiting the La Brea Tar Pits and Museum.

Evening

Have a memorable dinner at Republique, a restaurant housed in a historic building. Afterward, take a walk along Third Street Promenade.

Bedtime

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La Brea Tar Pits and Museum
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Outdoor Adventures

Morning

Start your day with a breakfast at The Griddle Cafe. Then, take a Hiking Tour of Runyon Canyon for panoramic views of the city.

Afternoon

For lunch, enjoy the food at Jon & Vinny's, a popular spot for casual Italian fare. In the afternoon, visit the El Matador Beach for a relaxing afternoon by the sea.

Evening

Have a casual dinner at Gjelina, a trendy restaurant known for its wood-fired dishes. Afterward, explore the nightlife of Abbot Kinney Boulevard.

Bedtime

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Hiking Tour of Runyon Canyon
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4.96
El Matador Beach
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From Los Angeles to Las Vegas

Morning

Start your day with a quick breakfast at Eggslut. Then, catch a flight from Los Angeles to Las Vegas.

Afternoon

Upon arrival in Las Vegas, have a late lunch at In-N-Out Burger, a must-try for any visitor to the city. Afterward, check into your hotel and take some time to relax.

Evening

For dinner, enjoy the modern American cuisine at Nopa. Afterward, take a leisurely walk along the Las Vegas Strip and enjoy the vibrant lights and entertainment.

Bedtime

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4.36
Las Vegas Strip
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The Glitz and Glamour of Vegas

Morning

Start your day with a classic Vegas breakfast at Eggslut. Then, take a Las Vegas Strip Helicopter Night Flight for a bird's eye view of the city.

Afternoon

For lunch, enjoy the food at Gordon Ramsay Hell's Kitchen, a restaurant inspired by the TV show. Spend the afternoon visiting the Bellagio Fountains and the Forum Shops at Caesars Palace.

Evening

Have a glamorous dinner at Joël Robuchon, a Michelin-starred restaurant. Afterward, take in a Cirque du Soleil Show for a truly Vegas experience.

Bedtime

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4.71
Bellagio Fountains
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Day of Luxury and Entertainment

Morning

Start your day with a leisurely breakfast at Mon Ami Gabi. Then, spend the morning relaxing by the pool at your hotel.

Afternoon

For lunch, enjoy the food at Bacchanal Buffet, a lavish buffet experience. In the afternoon, take a Helicopter Tour of the Grand Canyon for a breathtaking view of this natural wonder.

Evening

Have a gourmet dinner at Twist by Pierre Gagnaire, a restaurant with stunning views of the city. Afterward, try your luck at one of the Las Vegas Casinos.

Bedtime

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Farewell to Sin City

Morning

Enjoy a relaxed breakfast at Eggslut. Then, take a Red Rock Canyon Tour for a scenic escape from the city.

Afternoon

For lunch, have a picnic at Valley of Fire State Park with a takeout from In-N-Out Burger. Spend the afternoon exploring the park's unique rock formations.

Evening

Have a farewell dinner at Joël Robuchon, savoring the last moments of your Vegas culinary experience. Afterward, take a High Roller Observation Wheel Ride for a final view of the city.

Bedtime

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From Las Vegas to San Francisco

Morning

Start your day with a quick breakfast at Eggslut. Then, catch a flight from Las Vegas to San Francisco.

Afternoon

Upon arrival in San Francisco, have a late lunch at In-N-Out Burger, a must-try for any visitor to the city. Afterward, check into your hotel and take some time to relax.

Evening

For dinner, enjoy the modern American cuisine at Nopa. Afterward, take a leisurely walk along the San Francisco Bay.

Bedtime

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4.60
San Francisco Bay
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San Francisco Farewell

Morning

Start your last day in San Francisco with a classic breakfast at Tartine Bakery. Then, take a San Francisco Bridge to Bridge Cruise for a final view of the city from the water.

Afternoon

For lunch, enjoy the food at Swan Oyster Depot, a local institution. Spend the afternoon visiting the Exploratorium and the Ghirardelli Square.

Evening

Have a farewell dinner at Gary Danko, savoring the last moments of your San Francisco culinary experience. Afterward, take a San Francisco California Sunset Boat Cruise for a magical end to your trip.

Bedtime

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4.71
San Francisco Bridge to Bridge Cruise
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4.28
Ghirardelli Square
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Return Home

Morning

Enjoy a leisurely breakfast at Tartine Bakery. Then, take a San Francisco Small-Group City Tour by Vintage VW Bus to revisit some of the city's highlights.

Afternoon

For lunch, have a picnic at Golden Gate Park with a takeout from Tartine Bakery. Spend the afternoon exploring the park and visiting the California Academy of Sciences.

Evening

Have a farewell dinner at Gary Danko, known for its impeccable service and exquisite food. Afterward, take a San Francisco California Sunset Boat Cruise for a final view of the city.

Bedtime

Find amazing hotels in San Francisco.

4.92
San Francisco Small-Group City Tour by Vintage VW Bus
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4.49
Golden Gate Park
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End of the Journey

Morning

Start your last day with a relaxed breakfast at Tartine Bakery. Then, take a San Francisco Golden Gate Bay Cruise for a final view of the city from the water.

Afternoon

For lunch, enjoy the food at Swan Oyster Depot, a local institution. Spend the afternoon visiting the Exploratorium and the Ghirardelli Square.

Evening

Have a farewell dinner at Gary Danko, savoring the last moments of your San Francisco culinary experience. Afterward, take a San Francisco California Sunset Boat Cruise for a magical end to your trip.

Bedtime

Find amazing hotels in San Francisco.

4.70
San Francisco Golden Gate Bay Cruise
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4.28
Ghirardelli Square
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