Ultimate 16-Day South American Adventure Itinerary

Start with a fresh brew at Blue Bottle Coffee, and then embark on a full-day wine tour to the renowned Maipo Valley (Valle del Maipo). Visit prestigious wineries such as Concha y Toro and Santa Rita, where you'll learn about the winemaking process and indulge in world-class tastings. Pair the wines with a sumptuous lunch amid the picturesque vineyards.

After returning to the city, take a leisurely stroll through the beautifully landscaped Cerro Santa Lucía, a tranquil urban oasis. Continue to the nearby Sanhattan district to explore its upscale boutiques and galleries.

For dinner, enjoy the elegant ambiance and delectable French-inspired cuisine at El Preferido de Palermo. Cap off the evening with a breathtaking performance at the Santiago Municipal Theatre (Teatro Municipal), showcasing the best of Chilean and international talent.

Grab a quick breakfast at Panadería Rosetta before heading out on an excursion to the colorful port city of Valparaíso. Explore its steep hills, adorned with vibrant street art, and visit the house of Nobel laureate Pablo Neruda. Then, continue to the nearby resort town of Viña del Mar to enjoy its beautiful beaches and the famous flower clock.

Lunch awaits at Maximo Bistrot Local, a spot known for its seasonally inspired menu. Afterward, take a walk through the serene Viña Concha y Toro, one of the world's most renowned wineries, and learn about its rich history and winemaking process.

Return to Santiago and dine at Boragó, a restaurant that takes pride in showcasing Chilean ingredients in innovative ways. Conclude your day with a visit to Sky Costanera, the tallest building in Latin America, for stunning panoramic views of the city lights.

Kick off your day with a classic Argentine breakfast at La Cabrera, known for its delectable pastries. Then, take a guided tour of the majestic Teatro Colón, one of the world's top opera houses, and the historic Casa Rosada, where you'll learn about Argentina's rich political history.

For lunch, indulge in mouthwatering parrilla at Don Julio, a long-standing favorite for traditional Argentine barbecue. Afterward, stroll through the serene pathways of Jardín Japonés, a beautiful Japanese garden, and then visit the interactive El Ateneo Grand Splendid, a stunning bookstore located in a former theater.

Experience the passion of tango with an evening dinner show at Cafe de los Angelitos, one of Buenos Aires' most iconic tango venues. Enjoy a sumptuous meal as you're entertained by the sultry dance and music of Argentina. End the night with a cocktail at Florería Atlántico, a speakeasy bar hidden behind a florist's facade.

Start with a traditional Argentine breakfast at Pain de Sucre, and then set out for a full-day excursion to an estancia, where you'll experience the life of a gaucho. Enjoy horseback riding on the pampas, witness impressive gaucho skills, and indulge in a hearty asado lunch, a true taste of the Argentine countryside.

Return to the city and take a guided tour of the vibrant neighborhood of La Boca. Explore the colorful Caminito street, known for its tango history and local art, and visit the Boca Juniors Stadium (Estadio Alberto J. Armando), a shrine for football enthusiasts.

Dine at Parrilla Don Julio, a neighborhood parrilla known for its succulent steaks and warm ambiance. After dinner, take a leisurely stroll along the waterfront promenade of Puerto Madero, enjoying the modern architecture and the city lights reflecting on the Rio de la Plata.

Begin with breakfast at Las Pizarras Bistro, a cozy spot known for its chalkboard menu featuring fresh, seasonal ingredients. Then, immerse yourself in art at the Malba (Museo de Arte Latinoamericano de Buenos Aires), which houses an impressive collection of modern and contemporary Latin American art.

For lunch, enjoy the innovative Nikkei cuisine at Tomo 1, and then visit the Museo Evita to learn about the life and legacy of Argentina's iconic first lady, Eva Perón. Continue to the Recoleta Cemetery (Cementerio de la Recoleta) to explore its elaborate mausoleums and the final resting place of Eva Perón.

Dine at Elena, located in the stunning Palacio Duhau - Park Hyatt Buenos Aires. The restaurant's elegant setting is the perfect backdrop for its modern take on Argentine flavors. After dinner, enjoy a sophisticated cocktail at the hotel's Oak Bar, known for its extensive drink menu and refined ambiance.

Enjoy breakfast at Oviedo, a classic spot known for its Spanish cuisine. Then, take a morning boat ride through the lush Paraná Delta (Delta del Paraná), exploring its intricate network of rivers and islands. Arrive in the charming town of Tigre, where you can visit the Tigre Art Museum (Museo de Arte de Tigre) or browse the unique crafts at the Tigre Market.

For lunch, head to Azul Condesa to enjoy its contemporary Mexican cuisine in a stylish setting. Afterward, relax in the beautiful surroundings of the Tigre Municipal Museum (Museo Municipal de Tigre), housed in a historic building, or take a scenic ride on the Tren de la Costa, a coastal train offering panoramic views.

Return to Buenos Aires and dine at Pura Tierra, where the focus is on using the best local and seasonal ingredients to create innovative dishes. End the day with a visit to Suipacha, known for its vibrant nightlife and a wide range of bars and clubs.

Begin your day with a delightful breakfast at La Mar Cebicheria, and then set out to explore the historic heart of Montevideo. Visit the iconic Independence Plaza (Plaza Independencia) and the impressive Solís Theatre (Teatro Solís), and take a stroll along the promenade of Rambla of Montevideo, enjoying the fresh sea breeze.

For lunch, indulge in the mouthwatering offerings at La Cabrera, and then visit the Montevideo Metropolitan Cathedral (Catedral Metropolitana de Montevideo) and the Montevideo Cabildo (Cabildo de Montevideo) to immerse yourself in the city's history and culture. Later, explore the vibrant neighborhood of Pocitos, known for its beautiful beach and lively atmosphere.

Dine at El Preferido de Palermo, where the cozy ambiance and mouthwatering dishes will provide the perfect end to your day. After dinner, take a leisurely walk along the Punta Carretas neighborhood, enjoying its elegant shops and the serene Punta Carretas Shopping mall.

Start your day with a delicious breakfast at El Parnita, a spot known for its traditional Mexican flavors. Then, take a guided tour of the quirky and colorful neighborhood of La Boca, home to the famous Caminito street and the Boca Juniors stadium.

For lunch, enjoy the innovative dishes at Tegui, one of Buenos Aires' top restaurants. Afterward, explore the trendy and bohemian neighborhood of San Telmo, known for its antique shops, art galleries, and street tango performances.

Dine at Mishiguene, a restaurant that celebrates the flavors of Jewish immigrant cuisine. End the night with a visit to Costa Rica, a street in the Palermo neighborhood lined with bars and restaurants, offering a vibrant nightlife scene.

Catch an early flight to Iguazú, and upon arrival, fuel up with breakfast at a local cafe. Then, prepare to be awe-struck by the breathtaking power and beauty of Iguazú Falls (Cataratas del Iguazú), one of the most stunning waterfall systems in the world. Spend the morning exploring the numerous cascades and taking in the mesmerizing views from both the Argentine and Brazilian sides.

Refuel with a sumptuous lunch at El Preferido de Palermo, and then visit the Güirá Oga (House of Birds), a wildlife refuge where you can observe and learn about the region's diverse bird species and other native animals.

Return to Buenos Aires and enjoy a well-deserved dinner at Parrilla Don Julio, where you can savor the flavors of Argentina's renowned beef in a traditional parrilla setting.

Start your day with a leisurely breakfast at Lalo!, a popular spot known for its delicious pastries and coffee. Then, take a morning stroll through the lush greenery of Botanical Garden (Jardín Botánico), admiring the diverse plant species and serene landscapes.

For lunch, head to Central Restaurante to enjoy its innovative Scandinavian-inspired menu. Afterward, spend your afternoon exploring the stylish boutiques and galleries of the Palermo Soho and Palermo Hollywood neighborhoods, known for their vibrant arts and fashion scenes.

Dine at Rosetta, a charming restaurant that serves up exquisite Italian dishes in a refined setting. Cap off your evening with a visit to Konex Cultural Center (Centro Cultural Konex) in the lively neighborhood of Abasto, where you can enjoy live music or a performance art show in a unique and eclectic space.

Enjoy a delightful breakfast at Restaurante 040, and then immerse yourself in the history of Argentina at the National Historical Museum (Museo Histórico Nacional). Continue to the Museum of Latin American Art of Buenos Aires (MALBA) to explore its impressive collection of modern and contemporary art.

For lunch, indulge in the mouthwatering dishes at Paraje Arévalo, a spot known for its innovative menu. Afterward, take a guided tour of the majestic El Ateneo Grand Splendid, one of the world's most beautiful bookstores, housed in a stunning former theater.

Dine at Gran Dabbang, a restaurant that offers a fusion of flavors from around the world in a casual and eclectic setting. End your day with a visit to La Viruta, a popular spot for tango enthusiasts where you can take a dance lesson or simply enjoy the vibrant performances.

Start your day with a delicious breakfast at Restaurante 040, and then take a guided tour of the Teatro Colón, one of the world's top opera houses. Continue to the Casa Rosada for a visit to the presidential museum, and then explore the historic neighborhood of San Telmo, known for its cobblestone streets and antique shops.

For lunch, enjoy the innovative dishes at Paraje Arévalo, and then visit the Recoleta Cemetery (Cementerio de la Recoleta) to explore its elaborate mausoleums and the final resting place of Eva Perón. Afterward, relax in the serene surroundings of the Recoleta Cultural Center (Centro Cultural Recoleta), a dynamic cultural space that hosts exhibitions and performances.

Dine at Gran Dabbang, and then experience the vibrant nightlife of Buenos Aires in the Palermo Soho and Palermo Hollywood neighborhoods. Explore the eclectic mix of bars, live music venues, and dance clubs, and immerse yourself in the city's famous tango culture.

Start your day with a leisurely breakfast at Las Pizarras Bistro, and then take a morning stroll through the lush greenery of {A-Botanical Garden (Jardín Botánico) [114