Ultimate 5-Day Rome and Vatican City Cultural Tour Itinerary

Enjoy a delightful breakfast at La Pergola, the only three-Michelin-starred restaurant in Rome. Then, take a Vatican Museums & Sistine Chapel Entrance Ticket and immerse yourself in the artistic masterpieces of the Vatican Museums, culminating in the awe-inspiring Sistine Chapel.

For lunch, indulge in gourmet pizza at Pizzarium, a renowned pizzeria. Post-lunch, visit the majestic St. Peter's Basilica (Basilica di San Pietro) and explore its grandeur with a St. Peter's Basilica (Basilica di San Pietro).

Dine at Il Pagliaccio, a two-Michelin-starred restaurant offering innovative Italian cuisine. Afterward, take a leisurely walk in the charming streets of St. Peter's Square (Piazza San Pietro) and soak in the atmosphere of the Vatican at night.

Catch an early morning train to Florence and enjoy a breakfast at the famous Caffè Gilli. Spend the morning exploring the iconic Uffizi Galleries (Gallerie degli Uffizi) with a skip-the-line entry and guided tour, admiring works of art by the likes of Michelangelo, Leonardo da Vinci, and Botticelli.

Have a traditional Florentine lunch at Trattoria Da Cesare al Casaletto, known for its authentic Tuscan dishes. Afterward, visit the impressive Florence Duomo (Cattedrale di Santa Maria dei Fiori) and climb to the top of the dome for panoramic views of the city.

Enjoy a leisurely dinner at La Pergola, the oldest restaurant in Florence, before catching a train back to Rome.

Start your day with a visit to the lesser-known Borghese Gallery (Galleria Borghese), where you'll witness a stunning collection of art and sculptures. Take advantage of the skip-the-line entry with a Rome Borghese Gallery Entry with Skip-the-Line Tickets.

For lunch, head to Roscioli and indulge in their famous carbonara. Post-lunch, enjoy a guided golf cart tour of the Rome Imperial City, providing a unique and comfortable way to explore the ancient city's landmarks.

Dine at Il Pagliaccio, a culinary gem in the heart of Rome. Afterward, experience the vibrant atmosphere of Piazza Navona and witness the beautiful fountains and Baroque architecture.

Enjoy a relaxed morning with breakfast at Da Enzo al 29, reminiscing about your Roman culinary journey. Spend the rest of the morning exploring the city at your own pace, perhaps picking up some last-minute souvenirs.

For your final meal in Rome, head to Pizzarium and savor their delectable pizza by the slice. After lunch, take a serene walk through the Villa Borghese Gardens (Giardini di Villa Borghese) and reflect on your time in the Eternal City.

Depending on your departure time, you may opt for a transfer to Fiumicino Airport with a Rome Shuttle Bus Transfer to or from Fiumicino Airport or enjoy a leisurely evening in Rome before bidding the city farewell.