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![5-day trip to Rome and Vatican City](https://cdn.dev.beautifuldestinations.app/fc2d010c-0c0f-4c75-8126-b8ba9ddf3ff3/originalThumbnail.jpg)
5-day trip to Rome and Vatican City Itinerary
Last updated: 2024 Jun 14Exploring Ancient Rome
Morning
Start your day by visiting the iconic Colosseum. Take a guided tour to learn about its fascinating history and explore the Roman Forum and Palatine Hill. Afterward, grab a quick breakfast at Caffè Sant'Eustachio known for its delicious coffee.
Afternoon
Head to the Pantheon for a guided tour and marvel at its impressive architecture. For lunch, try the traditional Roman pasta at Da Enzo al 29, a local favorite. Afterward, take a stroll through the charming streets of Trastevere and explore its picturesque alleys and beautiful churches.
![Visit Rome Priority Access Colosseum, Roman Forum & Palatine Tour in Rome](https://cdn.getyourguide.com/img/tour/33cca66c19886c9f.jpeg/21.jpg)
4.62Colosseum
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![Visit Rome Priority Access Colosseum, Roman Forum & Palatine Tour in Rome](https://cdn.getyourguide.com/img/tour/33cca66c19886c9f.jpeg/21.jpg)
Colosseum
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![Visit Rome Pantheon Skip-the-Line Entry and Guided Tour in Rome](https://cdn.getyourguide.com/img/tour/e67214908b992c4a485b18094b84cb496234d6d6addb7238392f0ea47fd45133.jpg/21.jpg)
4.84Pantheon
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![Visit Rome Pantheon Skip-the-Line Entry and Guided Tour in Rome](https://cdn.getyourguide.com/img/tour/e67214908b992c4a485b18094b84cb496234d6d6addb7238392f0ea47fd45133.jpg/21.jpg)
Pantheon
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Vatican City Wonders
Morning
Start your day with a skip-the-line tour of the Vatican Museums & Sistine Chapel. Marvel at the stunning art collections and admire Michelangelo's masterpiece in the Sistine Chapel. Afterward, visit the magnificent St. Peter's Basilica and explore its grandeur.
Afternoon
For lunch, head to Osteria dell'Angelo near the Vatican for authentic Italian dishes. Afterward, take a leisurely walk along the Tiber River and enjoy the scenic views. You can also visit the Castel Sant'Angelo, a historic fortress with panoramic views of the city.
Evening
Enjoy a delightful dinner at Il Pagliaccio, a Michelin-starred restaurant known for its innovative cuisine. End the evening with a romantic stroll through the charming streets of Trastevere and stop by Freni e Frizioni for a cocktail.
Bedtime
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![Visit Vatican Museums & Sistine Chapel Entrance Ticket in Rome](https://cdn.getyourguide.com/img/tour/5f16d60b18470.jpeg/21.jpg)
4.50Vatican Museums & Sistine Chapel
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![Visit Vatican Museums & Sistine Chapel Entrance Ticket in Rome](https://cdn.getyourguide.com/img/tour/5f16d60b18470.jpeg/21.jpg)
Vatican Museums & Sistine Chapel
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![Visit Rome Vatican, Sistine Chapel and St. Peter's Basilica Tour in Rome](https://cdn.getyourguide.com/img/tour/60181bd5c978fc8e.jpeg/21.jpg)
4.62St. Peter's Basilica
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![Visit Rome Vatican, Sistine Chapel and St. Peter's Basilica Tour in Rome](https://cdn.getyourguide.com/img/tour/60181bd5c978fc8e.jpeg/21.jpg)
St. Peter's Basilica
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![Visit Coral Gables in Rome](https://media.tacdn.com/media/attractions-content--1x-1/0b/27/55/2b.jpg)
4.79Tiber River
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![Visit Coral Gables in Rome](https://media.tacdn.com/media/attractions-content--1x-1/0b/27/55/2b.jpg)
Tiber River
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![Visit Phillip and Patricia Frost Museum of Science (Frost Science) in Rome](https://media.tacdn.com/media/attractions-content--1x-1/0b/39/79/d7.jpg)
4.54Castel Sant'Angelo
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![Visit Phillip and Patricia Frost Museum of Science (Frost Science) in Rome](https://media.tacdn.com/media/attractions-content--1x-1/0b/39/79/d7.jpg)
Castel Sant'Angelo
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Hidden Gems of Rome
Morning
Explore the lesser-known attractions of Rome, starting with a visit to the Borghese Gallery. Admire the impressive art collection and stroll through the beautiful gardens. For breakfast, try the delicious pastries at Pasticceria De Bellis.
Afternoon
Take a guided tour of the Catacombs of Rome and explore the ancient underground burial sites. Afterward, enjoy a leisurely lunch at La Pergola in the Monte Mario neighborhood, known for its panoramic views of the city.
Evening
Experience a unique cooking class at Drunken Cooking Class, where you'll learn to make traditional pasta dishes and enjoy cocktails. End the day with a visit to Campo de' Fiori, a lively square with bustling nightlife. Grab a drink at Freni e Frizioni or Bar del Fico and soak in the vibrant atmosphere.
Bedtime
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![Visit Rome Borghese Gallery Ticket and Optional Audio Guide in Rome](https://cdn.getyourguide.com/img/tour/646272f67825a.jpeg/21.jpg)
4.12Borghese Gallery
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![Visit Rome Borghese Gallery Ticket and Optional Audio Guide in Rome](https://cdn.getyourguide.com/img/tour/646272f67825a.jpeg/21.jpg)
Borghese Gallery
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![Visit Rome Crypts and Catacombs Underground Tour with Transfers in Rome](https://cdn.getyourguide.com/img/tour/5a7aad55d60b4.jpeg/21.jpg)
4.55Catacombs of Rome
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![Visit Rome Crypts and Catacombs Underground Tour with Transfers in Rome](https://cdn.getyourguide.com/img/tour/5a7aad55d60b4.jpeg/21.jpg)
Catacombs of Rome
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![Visit Rome Traditional Pasta with Cocktails Drunken Cooking Class in Rome](https://cdn.getyourguide.com/img/tour/e17033a762ac651ac7190684cae38c76338ceb3a5423d7244e80cbf31fb5a986.jpg/21.jpg)
4.95Drunken Cooking Class
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![Visit Rome Traditional Pasta with Cocktails Drunken Cooking Class in Rome](https://cdn.getyourguide.com/img/tour/e17033a762ac651ac7190684cae38c76338ceb3a5423d7244e80cbf31fb5a986.jpg/21.jpg)
Drunken Cooking Class
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![Visit Palma Private Guided Walking Tour in Rome](https://cdn.getyourguide.com/img/tour/528e3ea8b4ce3.jpeg/21.jpg)
4.85Campo de' Fiori
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![Visit Palma Private Guided Walking Tour in Rome](https://cdn.getyourguide.com/img/tour/528e3ea8b4ce3.jpeg/21.jpg)
Campo de' Fiori
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Vatican City Highlights
Morning
Start your day with an early morning skip-the-line tour of the Vatican Museums & Sistine Chapel. Explore the Vatican's art collections and admire the stunning frescoes. Afterward, visit the St. Peter's Basilica and climb to the top of the dome for panoramic views of the city.
Afternoon
For lunch, try the delicious pizza at Pizzarium near the Vatican. Afterward, visit the Castel Sant'Angelo and learn about its fascinating history. Take a leisurely walk through the beautiful gardens of Villa Borghese and enjoy the peaceful atmosphere.
Evening
Enjoy a memorable dinner at La Pergola, a Michelin three-star restaurant located in Rome's Monte Mario neighborhood. Indulge in their exquisite Italian cuisine and enjoy the breathtaking views of the city.
Bedtime
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![Visit Rome Vatican Museums, Sistine Chapel, and Basilica Tour in Vatican City](https://cdn.getyourguide.com/img/tour/b64379eb32590b6e.jpeg/21.jpg)
4.31Vatican Museums & Sistine Chapel
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![Visit Rome Vatican Museums, Sistine Chapel, and Basilica Tour in Vatican City](https://cdn.getyourguide.com/img/tour/b64379eb32590b6e.jpeg/21.jpg)
Vatican Museums & Sistine Chapel
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![Visit Rome Vatican, Sistine Chapel and St. Peter's Basilica Tour in Vatican City](https://cdn.getyourguide.com/img/tour/60181bd5c978fc8e.jpeg/21.jpg)
4.62St. Peter's Basilica
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![Visit Rome Vatican, Sistine Chapel and St. Peter's Basilica Tour in Vatican City](https://cdn.getyourguide.com/img/tour/60181bd5c978fc8e.jpeg/21.jpg)
St. Peter's Basilica
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![Visit Phillip and Patricia Frost Museum of Science (Frost Science) in Vatican City](https://media.tacdn.com/media/attractions-content--1x-1/0b/39/79/d7.jpg)
4.54Castel Sant'Angelo
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![Visit Phillip and Patricia Frost Museum of Science (Frost Science) in Vatican City](https://media.tacdn.com/media/attractions-content--1x-1/0b/39/79/d7.jpg)
Castel Sant'Angelo
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![Visit Rome Borghese Gallery Ticket and Optional Audio Guide in Vatican City](https://cdn.getyourguide.com/img/tour/646272f67825a.jpeg/21.jpg)
4.12Villa Borghese
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![Visit Rome Borghese Gallery Ticket and Optional Audio Guide in Vatican City](https://cdn.getyourguide.com/img/tour/646272f67825a.jpeg/21.jpg)
Villa Borghese
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Day Trip to Pompeii and Amalfi Coast
Morning
Embark on a day trip to Pompeii and the Amalfi Coast. Explore the ancient ruins of Pompeii and marvel at the stunning coastal views of Amalfi. For breakfast, grab a quick bite at Roscioli Caffè Pasticceria near the Termini Station.
Afternoon
Enjoy a delicious seafood lunch at Ristorante Marina Grande in Amalfi and take a leisurely stroll along the picturesque streets. Don't forget to try the famous Limoncello of the region. In the late afternoon, head back to Rome.
Evening
End your trip with a farewell dinner at Hostaria Romana in Rome's historic center. Indulge in their traditional Roman dishes and toast to a memorable trip.
Bedtime
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![Visit From Rome Pompeii, Amalfi Coast and Positano Day Trip in Rome](https://cdn.getyourguide.com/img/tour/457d4382e4148914.jpeg/21.jpg)
4.55Pompeii
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![Visit From Rome Pompeii, Amalfi Coast and Positano Day Trip in Rome](https://cdn.getyourguide.com/img/tour/457d4382e4148914.jpeg/21.jpg)
Pompeii
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![Visit From Rome Pompeii, Amalfi Coast and Positano Day Trip in Rome](https://cdn.getyourguide.com/img/tour/457d4382e4148914.jpeg/21.jpg)
4.55Amalfi Coast
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![Visit From Rome Pompeii, Amalfi Coast and Positano Day Trip in Rome](https://cdn.getyourguide.com/img/tour/457d4382e4148914.jpeg/21.jpg)
Amalfi Coast
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![Visit From Rome Pompeii, Amalfi Coast and Positano Day Trip in Rome](https://cdn.getyourguide.com/img/tour/457d4382e4148914.jpeg/21.jpg)
4.55Limoncello
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![Visit From Rome Pompeii, Amalfi Coast and Positano Day Trip in Rome](https://cdn.getyourguide.com/img/tour/457d4382e4148914.jpeg/21.jpg)
Limoncello
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