Ultimate 6-Day Fort Myers and Sanibel Adventure Itinerary

Start with a visit to the Manatee Park to observe these gentle giants in their natural habitat. Enjoy a breakfast sandwich at Two Meatballs in the Kitchen before your encounter.

Afterward, head to the Six Mile Cypress Slough Preserve for a guided walk through the wetlands. For lunch, indulge in the fresh seafood at Blue Pointe Oyster Bar & Seafood Grill.

Conclude your day with a relaxing stroll at the Fort Myers Beach, followed by a beachfront dinner at The Firestone - Sky Bar & Martini Lounge, where you can enjoy both the cuisine and the view.

Take a day trip to nearby Sanibel Island and start with a hearty breakfast at The Melting Pot. Then, spend your morning shelling and enjoying the pristine beaches of Sanibel Island.

For lunch, head to Cibo Italian Restaurant for a taste of authentic Italian cuisine. Afterward, explore the unique exhibits at the Bailey-Matthews National Shell Museum and learn about the fascinating world of shells.

As the day winds down, savor a beachfront dinner at La Trattoria Cafe Napoli, known for its romantic ambiance and delicious dishes.

Begin with a visit to the Edison and Ford Winter Estates, where you can explore the homes and gardens of these famous inventors. Enjoy a breakfast with a view at The Boathouse Tiki Bar & Grill.

Afterward, take a leisurely drive along the Loop Road in the Big Cypress National Preserve, immersing yourself in the unique ecosystem. Stop for lunch at Twisted Vine Bistro, offering a diverse menu in a charming setting.

Conclude your day with a visit to the IMAG History and Science Center if you didn't have a chance to explore it fully on the first day. Then, enjoy a dinner cruise with Pure Florida - Fort Myers Sightseeing Sunset Cruise and take in the stunning views of the waterfront while enjoying a delicious meal onboard.

Start your day with a visit to the Calusa Nature Center and Planetarium, where you can explore the museum and the surrounding nature trails. Enjoy a breakfast at Ford's Garage, known for its unique automotive-themed setting.

Afterward, head to the Southwest Florida Museum of History to learn about the rich history of the region. For lunch, indulge in the gourmet burgers and craft beer selection at BurgerQue.

Enjoy a sophisticated dinner at The Bay House, offering a waterfront setting and a menu featuring fresh, local ingredients. After dinner, take a leisurely walk at the Mercato and explore the shops and entertainment options.

Begin with an adrenaline-pumping Cape Coral and Fort Myers Sanibel Causeway Jet Ski Tour, exploring the Sanibel Causeway and its surrounding waters. Refuel with a breakfast at The Standard, known for its modern American cuisine.

Spend your afternoon at Zoomers Amusement Park, enjoying the rides and attractions. For lunch, head to Taco Viva Fresh Mexican Grill for a quick and tasty Mexican meal.

Conclude your trip with a memorable Everglades Day Safari from Sanibel, Fort Myers & Naples, where you'll have the chance to see the diverse wildlife and unique ecosystem of the Everglades. After the safari, enjoy a farewell dinner at Osteria Celli Italian Cuisine, savoring the flavors of Italy in a warm and inviting atmosphere.