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Ultimate 22-Day Italy Exploration: Rome, Venice, Florence, Sicily, and Amalfi Coast

Ultimate 22-Day Italy Exploration: Rome, Venice, Florence, Sicily, and Amalfi Coast Itinerary

Last updated: 2024 Jun 14

Iconic Rome Kickoff

Morning
Start your Italian adventure with a Rome Skip-the-Line Tour to Colosseum, Forum, Palatine Hill. Witness the grandeur of the Colosseum, explore the ancient ruins of the Roman Forum, and enjoy the panoramic views from Palatine Hill. After the tour, grab a classic Italian breakfast at Bar del Fico, a local favorite.
Afternoon
Immerse yourself in the art and history of the Vatican with a Vatican Fast Entry Ticket of Museums and Sistine Chapel. Spend the afternoon admiring the masterpieces and conclude with a visit to the awe-inspiring Sistine Chapel. For lunch, head to Baccano, a stylish restaurant offering a mix of Roman and international cuisine.
Evening
Experience the vibrant atmosphere of Piazza Navona and enjoy the street performances. For dinner, indulge in the elegant setting of Granet Restaurant Bar & Terraces, where you can savor fine Italian dishes with a modern twist.
Bedtime
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Rome Guided Tour of Colosseum, Roman Forum & Palatine Hill

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Vatican Fast Entry Ticket of Museums and Sistine Chapel

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Piazza Navona

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Ancient Rome and Hidden Gems

Morning
Begin your day with a Rome Colosseum, Palatine Hill and Roman Forum Guided Tour. Delve deeper into the history of these iconic sites with an expert guide. After the tour, enjoy a delightful breakfast at The Barrel by Tyler, known for its artisanal coffee and pastries.
Afternoon
Explore the lesser-known attractions of Rome, starting with a visit to the Pantheon. Then, take a leisurely stroll to the Trevi Fountain (Fontana di Trevi) and make a wish. For lunch, head to Cul De Sac, a historic enoteca offering a wide selection of wines and delicious Roman dishes.
Evening
Dine at La Terrazza dei Papi Rooftop Restaurant, where you can enjoy panoramic views of the city while savoring traditional Italian cuisine. After dinner, take a romantic walk in the charming neighborhood of Trastevere, known for its narrow cobblestone streets and lively atmosphere.
Bedtime
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Rome Colosseum, Palatine Hill and Roman Forum Guided Tour

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Pantheon

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From Hermanus or Cape Town Shark Cage Diving Experience

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Trastevere

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Day Trip to Pompeii and Amalfi Coast

Morning
Embark on an unforgettable From Rome Pompeii, Amalfi Coast and Positano Day Trip. Explore the ancient ruins of Pompeii and then soak in the breathtaking views of the Amalfi Coast. Enjoy a light breakfast at Cybo before you depart.
Afternoon
Take a break from the historical sites and enjoy a relaxing lunch at Terrazza Borghese - Restaurant & Lounge Bar, offering a serene ambiance and a menu featuring fresh local ingredients. After lunch, continue your journey along the stunning coastline.
Evening
Return to Rome in the evening and unwind with a cocktail at Ambrosia Rooftop Restaurant & Bar, where you can reflect on the day's adventures with a view of the city skyline.
Bedtime
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From Rome Pompeii, Amalfi Coast and Positano Day Trip

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Gladiators and Evening Delights

Morning
Step back in time with a Rome Colosseum Tour with Access to the Gladiator Arena. Walk in the footsteps of ancient gladiators and learn about the spectacles that once took place in this iconic amphitheater. For breakfast, enjoy the artisanal offerings at Divinostilia food&winebar.
Afternoon
After the Colosseum, take a guided tour of the Roman Forum (Foro Romano) and Palatine Hill (Palatino) to complete your exploration of ancient Rome. For lunch, head to Cantina e Cucina, a trattoria known for its authentic Roman dishes and welcoming atmosphere.
Evening
As the sun sets, experience the Colosseum in a different light with a Rome Colosseum by Night with Underground & Arena Floor Tour. After the tour, enjoy a sophisticated dinner at Settimo Roman Cuisine & Terrace, offering a refined menu and a panoramic view of the city.
Bedtime
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Rome Colosseum Tour with Access to the Gladiator Arena

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Roman Forum (Foro Romano)

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Palatine Hill (Palatino)

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Rome Colosseum by Night with Underground & Arena Floor Tour

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Vatican Wonders and Culinary Delights

Morning
Beat the crowds with a Rome Priority Access Colosseum, Roman Forum & Palatine Tour. Explore the ancient sites with early access and then enjoy a hearty breakfast at I Sofà Bar Restaurant & Roof Terrace, known for its Roman classics.
Evening
For a memorable evening, enjoy a refined dining experience at Harry's Bar, a historic establishment known for its classic cocktails and elegant cuisine. After dinner, take a romantic walk to St. Peter's Square (Piazza San Pietro) and admire the grandeur of St. Peter's Basilica.
Bedtime
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Rome Priority Access Colosseum, Roman Forum & Palatine Tour

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Vatican Museums (Musei Vaticani)

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Sistine Chapel (Cappella Sistina)

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Rome Vatican Museums, Sistine Chapel, and Basilica Tour

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From Bilbao Vitoria and Rioja Day Tour

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Venetian Arrival and Canal Cruise

Morning
Arrive in Venice and start your day with a classic Venetian breakfast at Ai Tre Scalini. Then, take a Venice Grand Canal by Gondola with Commentary to immerse yourself in the unique atmosphere of the city.
Afternoon
After the gondola ride, visit the historic St. Mark's Basilica (Basilica di San Marco) and climb to the top of the St. Mark's Campanile (Campanile di San Marco) for a panoramic view of Venice. For lunch, enjoy the seafood specialties at Chez Moi Rome, a restaurant with a Venetian twist.
Evening
Spend a relaxing evening exploring the charming streets and hidden corners of Venice. For dinner, savor the local flavors at Salone Eva at Palm Court, a restaurant known for its elegant setting and traditional Venetian dishes.
Bedtime
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Vienna Tickets to Haus der Musik

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Campo de' Fiori

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Island Hopping and Artisanal Crafts

Morning
Take a boat trip to the nearby islands of Murano and Burano. In Murano, visit a traditional glassblowing factory and witness the skilled artisans at work. Then, head to Burano with its colorful houses and lace-making tradition. Enjoy a casual lunch at Granet Restaurant Bar & Terraces upon your return to Venice.
Afternoon
Explore the art scene of Venice with a visit to the Peggy Guggenheim Collection and the Gallerie dell'Accademia. Admire works by renowned artists and gain insight into the cultural heritage of the city. For a mid-afternoon pick-me-up, stop by The Bramble Bar & Kitchen for a refreshing drink and a snack.
Evening
Dine at La Terrazza dei Papi Rooftop Restaurant, where you can enjoy a romantic dinner with a view. Afterward, take a leisurely stroll along the canals and soak in the magical ambiance of Venice at night.
Bedtime
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Circus Maximus (Circo Massimo)

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Trastevere

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Hidden Gems and Culinary Delights

Morning
Discover the lesser-known corners of Venice with a walking tour of the Dorsoduro and Campo de' Fiori neighborhoods. For breakfast, enjoy the pastries and coffee at Divinostilia food&winebar.
Afternoon
Visit the offbeat attractions such as the Libreria Acqua Alta and the Chiesa di San Pantaleone (Chiesa di San Pantalon). For lunch, indulge in the innovative dishes at Terrazza Borghese - Restaurant & Lounge Bar, a hidden gem in the heart of Venice.
Evening
Experience the local nightlife at Apotheke Cocktail Bar, known for its creative cocktails and speakeasy atmosphere. Pair your drinks with some cicchetti, the Venetian version of tapas, for a true taste of the city.
Bedtime
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Piazza Navona

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Campo de' Fiori

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Pantheon

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Vienna Tickets to Haus der Musik

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Florence Arrival and Renaissance Welcome

Morning
Arrive in Florence and start your day with a visit to the Florence Duomo (Cathedral of Santa Maria del Fiore). Climb to the top of the Brunelleschi's Dome (Cupola del Brunelleschi) for a stunning panoramic view of the city. For breakfast, enjoy the elegant setting of Settimo Roman Cuisine & Terrace, offering a refined menu and a panoramic view of the city.
Afternoon
After the Duomo, explore the Uffizi Gallery (Galleria degli Uffizi) and admire the masterpieces of Renaissance art. For lunch, head to Cantina e Cucina, a trattoria known for its authentic Roman dishes and welcoming atmosphere.
Evening
Dine at La Terrazza dei Papi Rooftop Restaurant, where you can enjoy a romantic dinner with a view. Afterward, take a leisurely stroll along the canals and soak in the magical ambiance of Venice at night.
Bedtime
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Vienna Tickets to Haus der Musik

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Campo de' Fiori

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Vatican Museums (Musei Vaticani)

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Renaissance Marvels and Tuscan Flavors

Morning
Begin your day with a guided tour of the Uffizi Gallery (Galleria degli Uffizi), home to some of the most renowned works of art in the world. After immersing yourself in the beauty of the Renaissance, enjoy a delightful breakfast at The Barrel by Tyler, known for its artisanal coffee and pastries.
Afternoon
Explore the architectural wonders of Florence with a visit to the Florence Duomo (Cathedral of Santa Maria del Fiore) and the Brunelleschi's Dome (Cupola del Brunelleschi). Climb to the top of the dome for a panoramic view of the city. For lunch, indulge in the innovative dishes at Terrazza Borghese - Restaurant & Lounge Bar, a hidden gem in the heart of Venice.
Evening
Experience the vibrant Ponte Vecchio and the surrounding area, known for its lively atmosphere and charming shops. For dinner, savor the local flavors at Salone Eva at Palm Court, a restaurant known for its elegant setting and traditional Venetian dishes.
Bedtime
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Vatican Museums (Musei Vaticani)

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Vienna Tickets to Haus der Musik

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Campo de' Fiori

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Piazza Navona

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Tuscan Countryside and Wine Tasting

Morning
Take a break from the city and explore the picturesque Tuscany countryside. Visit a local winery and enjoy a guided wine tasting session, accompanied by the stunning views of the vineyards. For breakfast, enjoy the pastries and coffee at Divinostilia food&winebar.
Afternoon
After the wine tasting, continue your journey to the medieval town of San Gimignano. Explore the well-preserved architecture and enjoy a leisurely lunch at a local trattoria, savoring the flavors of the region.
Evening
Return to Florence and relax with a sunset walk along the Piazzale Michelangelo, offering panoramic views of the city. For dinner, indulge in the elegant setting of Granet Restaurant Bar & Terraces, where you can savor fine Italian dishes with a modern twist.
Bedtime
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Campo de' Fiori

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Circus Maximus (Circo Massimo)

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Piazza Navona

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Artisanal Crafts and Local Markets

Morning
Start your day with a visit to the Palazzo Vecchio, the historic seat of Florentine government. Explore the impressive chambers and enjoy the panoramic view from the Arnolfo Tower (Torre di Arnolfo). For breakfast, enjoy the artisanal offerings at Divinostilia food&winebar.
Afternoon
Discover the artisanal traditions of Florence with a visit to the Officina Profumo-Farmaceutica di Santa Maria Novella, one of the oldest pharmacies in the world. Then, explore the vibrant San Lorenzo Market (Mercato di San Lorenzo) and the surrounding area, known for its leather goods and local crafts. For lunch, enjoy the seafood specialties at Chez Moi Rome, a restaurant with a Venetian twist.
Evening
Dine at La Terrazza dei Papi Rooftop Restaurant, where you can enjoy a romantic dinner with a view. Afterward, take a leisurely stroll along the canals and soak in the magical ambiance of Venice at night.
Bedtime
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Vienna Tickets to Haus der Musik

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Campo de' Fiori

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Pantheon

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Circus Maximus (Circo Massimo)

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Day Trip to Pisa and Lucca

Morning
Embark on a day trip to the nearby cities of Pisa and Lucca. In Pisa, visit the iconic Leaning Tower of Pisa (Torre di Pisa) and the Pisa Cathedral (Duomo di Pisa). Then, continue to Lucca and explore the charming old town with its well-preserved city walls. For breakfast, enjoy the elegant setting of Settimo Roman Cuisine & Terrace, offering a refined menu and a panoramic view of the city.
Afternoon
Enjoy a leisurely lunch in Lucca, savoring the local specialties. Afterward, you can rent a bike and ride along the Lucca City Walls (Mura di Lucca), enjoying the views of the city and the surrounding countryside. For dinner, savor the local flavors at Salone Eva at Palm Court, a restaurant known for its elegant setting and traditional Venetian dishes.
Evening
Return to Florence and relax with a sunset walk along the Piazzale Michelangelo, offering panoramic views of the city. For dinner, indulge in the elegant setting of Granet Restaurant Bar & Terraces, where you can savor fine Italian dishes with a modern twist.
Bedtime
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Vienna Tickets to Haus der Musik

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Campo de' Fiori

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Circus Maximus (Circo Massimo)

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Piazza Navona

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Culinary Delights and Artistic Inspirations

Morning
Begin your day with a visit to the Gallerie dell'Accademia, home to the famous statue of David by Michelangelo. After immersing yourself in the world of Renaissance art, enjoy a delightful breakfast at The Barrel by Tyler, known for its artisanal coffee and pastries.
Afternoon
Explore the Oltrarno district, known for its artisan workshops and bohemian atmosphere. Visit the Boboli Gardens (Giardino di Boboli) and enjoy a leisurely stroll in the beautiful Renaissance garden. For lunch, indulge in the innovative dishes at Terrazza Borghese - Restaurant & Lounge Bar, a hidden gem in the heart of Venice.
Evening
Dine at La Terrazza dei Papi Rooftop Restaurant, where you can enjoy a romantic dinner with a view. Afterward, take a leisurely stroll along the canals and soak in the magical ambiance of Venice at night.
Bedtime
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Vatican Museums (Musei Vaticani)

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Campo de' Fiori

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Circus Maximus (Circo Massimo)

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Sicilian Welcome and Historical Wonders

Morning
Arrive in Sicily and start your day with a traditional Sicilian breakfast at Divinostilia food&winebar. Then, embark on a journey to the ancient Valley of the Temples (Valle dei Templi) in Agrigento, where you can explore the well-preserved Greek temples and enjoy the panoramic views of the surrounding landscape.
Afternoon
After immersing yourself in the ancient history, head to the charming town of Scala dei Turchi, known for its white limestone cliffs and crystal-clear waters. Relax on the beach and savor a picnic lunch with local Sicilian delicacies.
Evening
As the sun sets, return to Agrigento and enjoy a sumptuous dinner at Salone Eva at Palm Court, where you can taste the flavors of Sicilian cuisine in a refined setting.
Bedtime
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Vienna Tickets to Haus der Musik

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Campo de' Fiori

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Mount Etna and Taormina Treasures

Morning
Begin your day with an excursion to Mount Etna (Monte Etna), the highest active volcano in Europe. Explore the lunar landscapes and learn about the geological history of the area. For breakfast, enjoy the elegant setting of Settimo Roman Cuisine & Terrace, offering a refined menu and a panoramic view of the city.
Afternoon
After the volcanic adventure, head to the picturesque town of Taormina. Visit the ancient Greek Theatre (Teatro Greco) and enjoy the stunning views of the coast. For lunch, indulge in the local flavors at Granet Restaurant Bar & Terraces, where you can savor fine Italian dishes with a modern twist.
Evening
Take a leisurely walk through the charming streets of Taormina and explore the boutiques and artisan shops. For dinner, dine at La Terrazza dei Papi Rooftop Restaurant, where you can enjoy a romantic meal with a view of the town and the sea.
Bedtime
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Vatican Museums (Musei Vaticani)

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Campo de' Fiori

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Circus Maximus (Circo Massimo)

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Baroque Splendor of Noto and Siracusa

Morning
Begin your day with a visit to the Noto, a UNESCO World Heritage site known for its stunning Baroque architecture. Explore the elegant palaces and churches, and enjoy a traditional Sicilian breakfast at The Barrel by Tyler.
Afternoon
Evening
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Vatican Museums (Musei Vaticani)

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